At what point does the car become too tired, even if it has been immaculately maintained?
If in the rust belt, and driven during winter, it would seem that the body would rust away before all of the mechanicals were beyond their effective service life.
Dunno what could really be done to save the body, but I would have to say a low mile car with limited service history would be my choice inside the rust belt.
Outside the rust belt... the car that was better maintained, regardless of mileage, would be my choice.